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Wunderlich 6000 Poplar

ALAN HOWELL | MBJ

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Reporter, Memphis Business Journal

Owners of a Memphis-based financial firm with more than 100 local employees agreed to sell the company Thursday to a publicly traded, Los Angeles-based firm.

Wunderlich Securities, which has 25 offices in 17 states, was Memphis' No. 59 largest private company by annual revenue in 2015, according to Memphis Business Journa l research. It ranks No. 7 on MBJ's investment security brokers List, with 33 local brokers.

The buyer, Clearance Wide Range Of Online Sale Donna Karan Suede PointedToe Pumps Sunshine Professional Cheap Online FAGGAL
, paid $67 million for the Memphis company in cash and common stock. The company made the purchase in an effort to add to its client base, gain expertise and add a steady cash flow, according to a news release.

B. Riley expects to "realize substantial cost synergies," which could lead to changes in Wunderlich's Memphis office.

Gary Wunderlich, Wunderlich Securities CEO, is set to continue in his role there and join B. Riley's board of directors.

"We believe their platform is highly complementary to our business and will provide our expanded client base with a broader suite of products and services to better meet their financial needs," Wunderlich said in the release.

Wunderlich generated $116.9 million in revenue over the trailing 12-month period that ended March 31. Its more than 200 financial advisors managed about 37,000 accounts at the end of March.

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Thursday, May 18, 2017

You are invited to join us as we honor the Memphis Business Journal's 2017 Small Business Awards finalists. Come join us as we celebrate small business and the impact that it makes in our community.

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Lee, Sang Chul; Jeong, Hye Jin; Lee, Sang Kuon

Adipose-derived stem cells (ASCs) mainly exert their function by secreting materials that are collectively termed the secretome. Despite recent attention to the secretome as an alternative to stem cell therapy, the culture conditions for generating optimal secretome contents have not been determined. Therefore, we investigated the role of hypoxic-conditioned media (HCM) from ASCs. Normoxic-conditioned media (NCM) and HCM were obtained after culturing ASCs in 20% O2 or 1% O2 for 24 hours, respectively. Subsequently, partially hepatectomized mice were infused with saline, control medium, NCM, or HCM, and then sera and liver specimens were obtained for analyses. Hypoxia (1% O2) significantly increased mRNA expression of mediators from ASCs, including interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), hepatocyte growth factor (HGF), and vascular endothelial growth factor (VEGF). HCM infusion significantly increased the number of Ki67-positive cells in the liver (p < .05). HCM infusion significantly increased phospho-signal transducer and activator of transcription 3 (STAT3) and decreased suppressor of cytokine signaling 3 (SOCS3) expression in the liver (p < .05). To determine the role of IL-6 in liver regeneration , we then performed IL-6 RNA interference study. Conditioned media (CM) obtained from ASCs, which were transfected with either siIL-6 or siControl, were administered to partially hepatectomized mice. The siIL-6 CM groups exhibited lower liver proliferation (Ki67-positive cells) and markers of regeneration (protein expression of proliferating cell nuclear antigen, p-STAT3, HGF, and VEGF and liver weights) than the siControl CM groups (p < .05). Taken together, hypoxic preconditioning of ASCs increased expression of mediators promoting anti-inflammatory and regenerative responses. The liver regenerative effects of HCM appear to be mediated by persistent and uninhibited expression of STAT3 in the liver , which results from decreased expression of SOCS3

Rat Stem-Cell Factor Induces Splenocytes Capable Of Regenerating The Thymus

Migita, Russell T.; Trebasky, Lisa D.; Housman, Jerry M.; Elliott, Gary S.; Hendren, R. Wayne; Deprince, Randolph B.; Greiner, Dale L.

Cytokine regulation of prethymic T-lymphoid progenitor-cell proliferation and/or differentiation has not been well-defined, although much is known of cytokine regulation of hemopoietic stem- and progenitor-cell development. Here we use a recently identified hemopoietic growth factor, stem-cell factor (SCF) (a form of the c-kit ligand), and a transplant model of thymocyte regeneration to assess the effect of SCF on the in vivo generation of prethymic, thymocyte progenitor-cell activity. We show that recombinant rat SCF (rrSCF164 administered to weanling rats selectively induces an increase in thymocyte progenitor activity in the spleens of treated rats as compared to rats treated with vehicle, polyethylene glycol (PEG)-conjugated rat albumin, or recombinant human granulocyte colony-stimulating factor (rhG-CSF). These data demonstrate that administration of SCF in vivo affects extrathymic-origin thymocyte regenerating cells and may influence, directly or indirectly, early prethymic stages of T-cell lymphopoiesis in addition to its known effect on early stages of myelopoiesis and erythropoiesis. PMID:1285280

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